Genus Vernonia (Asteraceae): A Promising Source of Antitumor Agents with Pharmacological Potentials

Antitumor research leads to the development of new molecules that act specifically in tumor cells by blocking or inhibiting their molecular targets. New therapeutic approaches for screening bioactive compounds present medicinal plants have received increasing attention due chemopreventive and chemotherapeutic properties. In ethnomedicine, genus Vernonia (Asteraceae) are widely used some shown several interesting biological activities, including anticancer. This study aimed document experimental evidence supporting claimed ethnomedical uses species treatment various types cancer also confirm anticancer potential these plants. The isolated from aqueous alcoholic extracts, as well fractions different parts acted agents inhibited proliferation human cell lines, cervical cells, melanoma promyelocytic leucemia breast adenocarcinoma ovarian cancer, liver cell, lung cells. Studies correlated antitumor activity inducing apoptosis modulating mitochondrial signaling pathways controlled NF-κB, Bcl-2 p53, DNA damage arresting cycle at S-phase checkpoint oxidative stress. conclusion, a promising source drug development. However, further studies needed explore exact mechanism action, pharmacokinetics, chronic toxicological studies, safe dose consumption, possible interactions with other herbs.